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用高效液相色谱法测定了6名健康志愿者口服二种尼莫地平片剂的相对生物利用度和药代动力学参数。结果表明:尼莫地平在人体内的浓度—时间数据可用一室开放模型拟合,主要动力学参数与国外文献报道一致。新片剂和普通片的人体相对生物利用度分别为82.39%和16.01%。
The relative bioavailability and pharmacokinetic parameters of two nimodipine tablets in six healthy volunteers were determined by high performance liquid chromatography. The results showed that the concentration-time data of nimodipine in human body can be fitted by one-compartment open model, and the main kinetic parameters are consistent with those reported in foreign literature. The relative bioavailability of the new tablet to the normal tablet was 82.39% and 16.01%, respectively.