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药物引起肾脏的不良反应引起不良反应的基本方式 1.直接损害肾脏或其功能:肾脏有丰富的血流供应,易受高血药浓度的影响。肾脏又是药物排泄的主要器官,随着肾小管内水盐不断被重吸收,肾小管内药物浓度逐步增高,可对肾小管发生影响。还有,肾脏具有特殊的逆流倍增系统,某些药物可在髓质细胞间液中达到很高浓度,形成损害。损伤原因往往与药物干扰细胞代谢中关键性的酶,尤其含巯基酶类有关。肾毒性与药物浓度及时间有密切关系,易见于大量、长期用药者。一般可在动物身上
Drugs cause kidney adverse reactions The basic way of adverse reactions 1. Direct damage to the kidneys or their function: Kidney is rich in blood supply, susceptible to high plasma concentrations. Kidney is the main organ excretion of drugs, with the tubal water and salt continue to be reabsorbed, tubular drug concentration gradually increased, can affect the tubules. Also, the kidneys have a special countercurrent doubling system, some of which can reach very high concentrations in the medullary compartment fluid and cause damage. Often the cause of injury and drugs interfere with the metabolism of key enzymes in cells, especially containing sulfhydryl enzymes. Nephrotoxicity and drug concentration and time are closely related, easy to find in large, long-term use of those. Generally available in animals