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目的 :观察慢性肾衰患者血小板四项参数的变化 ,探讨慢性肾衰患者存在出血倾象的原因。方法 :测定了 75例慢性肾衰患者血小板计数 (PLT)、平均血小板体积 (MPV)、血小板压积 (PCT)、血小板分布宽度 (PDW)、血色素 (Hb)、血尿素氮 (BUN)、血肌酐 (Scr) ,同时与 30例正常人进行对照 ,并用t检验、相关与回归分析了上述参数之间的关系。结果 :慢性肾衰患者MPV较正常人明显缩小 (P <0 .0 1) ,而PLT、PCT、PDW与正常人相比无明显变化 (P >0 .0 5 ) ,且MPV与Hb呈显著正相关 (r值为 0 41,P <0 .0 5 ) ,与Scr、BUN无相关。结论 :MPV缩小可能是慢性肾衰患者血小板功能障碍而发生出血的原因之一。
Objective: To observe the changes of four parameters of platelets in patients with chronic renal failure and to explore the causes of bleeding in patients with chronic renal failure. Methods: The PLT, MPV, PCT, PDW, BUN and BUN were measured in 75 patients with chronic renal failure. Creatinine (Scr), at the same time with 30 cases of normal controls and t-test, correlation and regression analysis of the relationship between the above parameters. Results: The MPV of patients with chronic renal failure was significantly lower than that of normal controls (P <0.01), while there was no significant difference between PLT, PCT, PDW and normal subjects (P> 0.05), and MPV and Hb were significant (R = 0 41, P <0.05), but not related to Scr and BUN. Conclusion: The reduction of MPV may be one of the causes of bleeding in platelet dysfunction in patients with chronic renal failure.