论文部分内容阅读
本文探讨心率变异性（heartratevariability，HRV）频谱中高频成分的中枢机理。对正常SD大鼠给予不同频率的人工通气并电刺激延髓疑核，观察HRV频谱的改变，记录与呼吸节律同步的延髓头端腹外侧区（rostralventrolateralmedulla,rVLM）及其周围区神经元细胞外单位放电，对HRV和放电变异性进行相干函数分析。结果显示：（1）HRV的高频成分的中心频率随着人工通气频率的增加而增加，呈高度线性相关，（r=0.83，P＜0．0001）；（2）对rVLM及其周围区与呼吸节律同步的神经元细胞外单位放电和HRV同时进行频谱分析，两者的高频峰呈良好的相关，相干系数k2=0．854±0．1；（3）间断电刺激延髓疑核时，HRV高频成分显著增加。实验直接提示rVLM区参与对HRV的高频调节，HRV的高频成分反映了迷走中枢的波动性活动。
This article explores the central mechanism of high-frequency components of the heart rate variability (HRV) spectrum. The normal SD rats were given different frequencies of artificial ventilation and electrical stimulation of medullary suspicious nuclei. Changes of HRV spectrum were observed. Routine ventrolateral medulla (rVLM) synchronized with respiratory rhythm and peripheral neurons extracellular units Discharge, coherence function analysis of HRV and discharge variability. The results showed that: (1) The center frequency of high frequency components of HRV increased with the increase of artificial ventilation frequency and was highly linearly correlated (r = 0.83, P <0.0001); (2) The extracellular unit discharge synchronized with respiration rhythm and HRV spectrum analysis at the same time showed a good correlation between the two high frequency peaks, the correlation coefficient k2 = 0.854 ± 0.1; (3) HRV high frequency components increased significantly. The experiment directly suggested that the rVLM region is involved in the high frequency regulation of HRV, and the high frequency component of HRV reflects the fluctuating activity of the vagus center.