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(一)引言1949年 Hench 等发现了副肾皮酮(Cortisone)对风湿性关节炎具有特出的疗效之后,甾体化学的研究又再度进入一个高潮。在以后的七八年间,有机化学家不但对副肾皮甾体激素的半合成方法提供不少新的原料和合成途径,而且也创造了将近十个的饱和甾核的全合成方法。近几年来甾体的微生物氧化的发展,在实用上大大地简化了半合成的步骤,它的应用范围以及生化机制等都有待深入研究,发展前途
(A) Introduction In 1949, Hench and others found that Cortisone has an exceptional curative effect on rheumatoid arthritis, and the study of steroidal chemistry has once again reached a climax. In the next seven or eight years, organic chemists have not only provided a lot of new raw materials and synthetic routes for the semi-synthetic method of adrenal steroid hormones, but also created nearly 10 complete synthetic methods for saturated steroidal nuclei. In recent years, the development of microbial oxidation of steroids has greatly simplified the semi-synthesis step, its application and biochemical mechanisms have yet to be further studied and developed.