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近年来,心血管局部肾素—血管紧张素系统(RAS)的发现,引起了人们高度重视。曾有人发现,外源性血管紧张素Ⅱ(AngⅡ)可促进离体心房组织核酸的蛋白质合成。但有关AngⅡ、AngⅠ和血管紧张素转换酶抑制剂(ACEI,如巯甲丙脯酸)对心室肌细胞的直接作用的研究尚未见报道。最近,我们采用同位素(~3H-TdR和~(14)C-UR)双标记测量和单个心肌细胞平均蛋白含量测定法证实,AngⅡ(5×10~(11)mol/L和AngⅠ(3×10~(-9)mol/L)
In recent years, the discovery of the cardiovascular renin-angiotensin system (RAS) has aroused people’s attention. It has been found that exogenous angiotensin Ⅱ (Ang Ⅱ) can promote isolated atrial tissue nucleic acid protein synthesis. However, no studies have been reported on the direct effects of angiotensin II, Ang I and angiotensin-converting enzyme inhibitors (ACEIs, such as captopril) on ventricular myocytes. Recently, we used double isotope labeling (~ 3H-TdR and ~ (14) C-UR) and single cardiomyocyte average protein content assay to confirm that AngⅡ (5 × 10-11 mol / L and AngⅠ 10 ~ (-9) mol / L)