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变形链球菌在形成牙菌斑中重要的特性之一就是合成由细胞外葡萄糖基转移酶催化的不溶性葡聚糖(ISG)。本文作者分别从丁香的乙醚提取液和酸枣仁的氯仿提取液中分离得到鱼肝油酸和熊果酸,发现他们能抑制变形链球菌的葡糖基转移酶的不溶性葡聚糖的形成,抑制合成的程度与鱼肝油酸或熊果酸的浓度有关,在浓度为100μg/ml时,鱼肝油酸和熊果酸几乎完全抑制不溶性葡聚糖的合成,他们抑制葡糖基转移酶的剂量反应曲线是双相的。
One of the important properties of Streptococcus mutans in the formation of plaque is the synthesis of insoluble glucans (ISGs) catalyzed by extracellular glucosyltransferases. In this paper, the author separately from the clove ether extract and wild jujube kernel chloroform extract obtained from liver oleic acid and ursolic acid found that they can inhibit Streptococcus mutans Glucosyltransferase insoluble glucan formation, inhibit the synthesis of The degree is related to the concentration of oleic acid or ursolic acid, and almost completely inhibits the synthesis of insoluble glucans at a concentration of 100 μg / ml. The dose response curves for their inhibition of glucosyltransferase are biphasic of.