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β2微球蛋白(β2m)是人体HLA分子的轻链部分。正常血循环中的β2m经肾小球滤过后,99.9％以上由近球小管重吸收和代谢〔l〕。我们测定74例泌尿系疾病的尿液β2m,’并探讨其与肾小管-间质病变的关系。 材料与方法 一、观察对象74例中男39例,女35例,平均年龄38岁。其中慢性肾小球疾病44例,全部经肾组织活检证实。计系膜增殖性肾炎15例,局灶性硬化7例,膜增殖性肾炎4例,内皮系膜增殖性肾炎3例,微小病变1例,狼疮性肾炎14例。慢性间质性肾炎4例,亦经病理确诊。
β2 microglobulin (β2m) is the light chain portion of a human HLA molecule. Normal blood circulation in the β2m by glomerular filtration, 99.9% by the proximal bulb reabsorption and metabolism 〔l〕. We measured urinary β2m in 74 urologic diseases and explored its association with tubulointerstitial lesions. Materials and methods First, the observed object 74 patients, 39 males and 35 females, with an average age of 38 years. 44 cases of chronic glomerular disease, all confirmed by renal biopsy. Mesenteric proliferative glomerulonephritis in 15 cases, focal sclerosis in 7 cases, 4 cases of membranoproliferative glomerulonephritis, 3 cases of mesangial proliferative glomerulonephritis, 1 case of minimal lesion, 14 cases of lupus nephritis. 4 cases of chronic interstitial nephritis, also confirmed by pathology.