Background:Common B cell lymphoma locations are lymph nodes,skin,bone,mediastinum and it accounts for 2 ％ of NHL.Giant solitary spinal B-LBL has not yet been described.Case presentation:A 15-years old boy was admitted for a painful swelling of the thoracolumbar spine and paraplegia.MRI showed a voluminous mass of the thoracolumbar spine.Initial treatment consisted of surgical decompression and stabilization,followed by chemotherapy and radiotherapy.Histological examination showed a B-LBL.The quality of life improved significantly.Conclusion:To the best of our knowledge,this is the first case of giant solitary spinal B-LBL ever reported.Indication to choose a treatment method over another should weigh on individual priorities.Surgery should be considered as initial treatment option in this atypical lesion.