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实验性佝偻病雏鸡在每日滴喂六味地黄汤浓煎剂条件下,两个月内,血清钙、磷浓度均高于不给药的佝偻病鸡组;而碱性磷酸酶活性则低于不给药的佝偻病鸡组。两个月后,X 线诊断证明不给药的佝偻病组严重,患病率高达65.5%,而给药组仅为16.7%。不给药组的胫骨灰分中钙、磷含量明显低于给药组(P<0.05)。滋阴补肾药物的上述效应机理可能在于药物本身含有麦角骨化醇等天然的抗佝偻病成分,或者由于增强肾的生理功能,调节了钙磷代谢的平衡。
The experimental diarrhoea chicks were fed with Liuwei Dihuang Decoction daily. Within two months, serum calcium and phosphorus concentrations were higher than those of non-administered diarrhea chickens; alkaline phosphatase activity was lower than no. The drug’s rickets chicken group. Two months later, X-ray diagnosis confirmed that the non-administered rickets group was severe, with a prevalence of 65.5%, compared with 16.7% in the drug administration group. The content of calcium and phosphorus in tibia ash of the non-administration group was significantly lower than that of the administration group (P<0.05). The above-mentioned effect mechanism of Ziyin Bushen medicine may be that the medicine itself contains natural anti-caries component such as ergocalciferol, or it may regulate the balance of calcium and phosphorus metabolism due to the enhancement of the physiological function of the kidney.