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目的 :探讨乳腺浸润性小叶癌PCNA、p5 3的表达及意义。 方法 :采用免疫组化S -P法 ,对 5 4例浸润性小叶癌进行检测 ,用有关统计学方法结合随访资料进行分析。结果 :浸润性小叶癌PCNA阳性率为 90 74% (49/5 4) ,PCNA平均指数 5 1 5 0 %± 2 2 49% ,PCNA指数与临床分期、淋巴结转移有密切关系 (P <0 0 1)。随PCNA指数升高 ,浸润性小叶癌患者生存期缩短 (P <0 0 1)。但浸润性小叶癌p5 3阳性率仅为 3 70 % (2 / 5 4)。结论 :1)PCNA可作为反映浸润性小叶癌增殖活性 ,预测预后的重要指标。 2 ) p5 3免疫组化检测不能作为浸润性小叶癌的有用指标 ,需探讨其它的检测方法。 3)进一步显示浸润性小叶癌与来源于导管上皮的乳腺癌的某些生物学特征可能不同。
Objective: To investigate the expression and significance of PCNA and p53 in invasive lobular carcinoma of breast. METHODS: Fifty-four invasive lobular carcinomas were detected by immunohistochemical S-P method. Statistical analysis was combined with follow-up data. Results: The positive rate of PCNA in invasive lobular carcinoma was 90 74% (49/5 4), and the average PCNA index was 5 1 50% ± 2 2 49%. The PCNA index was closely related to clinical stage and lymph node metastasis (P <0. 1). With the increase of PCNA index, the survival time of patients with invasive lobular carcinoma was shortened (P < 0 01). However, the positive rate of p53 in invasive lobular carcinoma was only 37% (2/54). Conclusion : 1) PCNA can be used as an important index to reflect the proliferative activity of invasive lobular carcinoma and predict its prognosis. 2) p5 3 immunohistochemistry can not be used as a useful indicator of invasive lobular carcinoma, and other detection methods need to be explored. 3) It may be further shown that certain biological characteristics of invasive lobular carcinoma and breast carcinoma derived from ductal epithelium may be different.