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目的观察联合用药治疗冠心病合并脑梗死对患者动脉粥样硬化程度及血清同型半胱氨酸(Hcy)、胱抑素C(Cys-C)水平的影响。方法将冠心病合并脑梗死患者216例随机分为试验组和对照组各108例。试验组给予阿托伐他汀联合苯磺酸氨氯地平治疗,对照组仅给予苯磺酸氨氯地平治疗,观察2组患者治疗前后血清Hcy、Cys-C水平变化和动脉粥样硬化程度。结果试验组患者治疗后动脉粥样硬化Ⅰ级和恢复正常比例均高于对照组,而治疗后2组患者血清Hcy和Cys-C水平均低于治疗前,且试验组低于对照组,差异均有统计学意义(P<0.05)。结论联合用药治疗冠心病合并脑梗死可有效改善患者动脉粥样硬化程度,降低血清Hcy和Cys-C水平。
Objective To observe the effects of combination therapy on atherosclerosis and serum levels of homocysteine (Hcy) and cystatin C (Cys-C) in patients with coronary heart disease complicated with cerebral infarction. Methods 216 cases of coronary heart disease complicated with cerebral infarction were randomly divided into experimental group and control group of 108 cases. The experimental group was treated with atorvastatin combined with amlodipine besylate, while the control group only treated with amlodipine besylate. The changes of serum Hcy and Cys-C levels and the degree of atherosclerosis were observed in two groups before and after treatment. Results After treatment, the level of atherosclerosis Ⅰ and the recovery rate of the patients in the experimental group were higher than those in the control group, while the levels of Hcy and Cys-C in the two groups after treatment were lower than those before treatment, and the levels in the experimental group were lower than those in the control group All were statistically significant (P <0.05). Conclusion Combined treatment of coronary heart disease with cerebral infarction can effectively improve the degree of atherosclerosis and reduce serum Hcy and Cys-C levels.