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目的比较表皮生长因子受体(EGFR)自身抗体在健康志愿者、肺癌患者及肺结核患者血清中的差异,并探讨相关的临床意义。方法利用间接ELISA方法检测100名健康志愿者,112例肺结核患者,317例非小细胞肺癌患者血清中EGFR自身抗体的含量。结果EGFR自身抗体在健康志愿者血清中的相对含量(1.475±0.806)与肺癌患者血清中的相对含量(1.625±0.988)相比,差异无统计学意义(t=1.533,P=0.127);而EGFR自身抗体在肺结核患者(2.298±1.414)与健康志愿者(1.475±0.806),肺结核患者(2.298±1.414)与肺癌患者(1.625±0.988)血清中的相对含量的差异均有统计学意义(t=5.277,P=0.022;t=4.566,P=0.043)。结论EGFR自身抗体在肺结核患者中含量最高,在健康志愿者血清中含量最低,EGFR自身抗体血清含量的差异有可能为肺结核和肺癌患者的鉴别诊断提供线索和依据。
Objective To compare the differences of serum autoantibodies against epidermal growth factor receptor (EGFR) in healthy volunteers, lung cancer patients and pulmonary tuberculosis patients and to explore the clinical significance. Methods The serum levels of EGFR autoantibodies in 100 healthy volunteers, 112 pulmonary tuberculosis patients and 317 non-small cell lung cancer patients were detected by indirect ELISA. Results The relative content of EGFR autoantibodies in serum of healthy volunteers (1.475 ± 0.806) was not significantly different from that of lung cancer patients (1.625 ± 0.988) (t = 1.533, P = 0.127) The relative content of EGFR autoantibodies in serum of patients with pulmonary tuberculosis (2.298 ± 1.414) and healthy volunteers (1.475 ± 0.806), tuberculosis patients (2.298 ± 1.414) and lung cancer patients (1.625 ± 0.988) was statistically significant (t = 5.277, P = 0.022; t = 4.566, P = 0.043). Conclusion The highest level of EGFR autoantibodies in patients with pulmonary tuberculosis and the lowest level in the serum of healthy volunteers may provide clues and basis for the differential diagnosis of patients with pulmonary tuberculosis and lung cancer.