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本文报道用巯甲丙脯酸(CPT)治疗慢性活动型肝炎(CAH)64例。其中合并肝硬化失代偿14例,随机分为治疗组和对照组各32例。疗程结束时治疗组血清胆红质(SB)及谷丙转氨酶(ALT)恢复正常者分别为93.1%及93.33%,对照组分别为50%及57.14%。两组间有显著性差异(P<0.01)。治疗组血浆ATⅡ值由治前138.92±63.7pg/ml下降至67.21pg/ml±47.21pg/ml。治疗前后差异明显,(P<0.01)。
This article reports 64 cases of chronic active hepatitis (CAH) treated with captopril (CPT). 14 cases of decompensated cirrhosis were randomly divided into treatment group and control group, 32 cases each. At the end of treatment, the levels of serum bilirubin (SB) and alanine aminotransferase (ALT) in the treatment group recovered to 93.1% and 93.33%, respectively, while those in the control group were 50% and 57.14%, respectively. There was a significant difference between the two groups (P <0.01). The plasma ATⅡ level in the treatment group decreased from 138.92 ± 63.7pg / ml to 67.21pg / ml ± 47.21pg / ml. The difference was significant before and after treatment (P <0.01).