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目的探讨妊娠后期抗病毒治疗阻断乙型肝炎病毒母婴传播的疗效与安全性。方法采用门诊治疗后并由病房收治的HBS阳性的产妇143例,其中治疗组71例给予妊娠后期抗病毒治疗。对照组72例从妊娠后期开始每月注射HB IG 200U。观察宫内感染率及不良反应。结果妊娠后期抗病毒治疗阻断乙型肝炎病毒母婴传播的疗效明显。近期安全性好,但远期安全性还有待进一步观察。
Objective To investigate the efficacy and safety of antiretroviral therapy during late pregnancy in blocking mother-to-child transmission of hepatitis B virus. Methods 143 outpatients were treated with outpatient HBS-positive mothers and were treated by antiviral therapy in 71 pregnant women in the treatment group. The control group, 72 cases from the second trimester of pregnancy received monthly HB IG 200U. Intrauterine infection rates and adverse reactions were observed. The results of late pregnancy antiviral therapy blocking hepatitis B virus mother to child transmission of the obvious effect. Recent security is good, but long-term security remains to be seen.