为了提高药物的生物利用度,人们致力改善难溶性药物的溶出速率,如采用共沉淀法和固态分散体等。作者用滚筒混合法制备了不同配比的硝苯啶-PVP体系,与共沉淀法和物理混合法进行了溶出速率的比较。硝苯啶的水中溶解度为8.25μg/ml(25℃),晶体的平均粒经约16μm。作者研究了不同型号和配比的PVP与药物滚筒混 In order to improve the bioavailability of drugs, people are committed to improving the dissolution rate of poorly soluble drugs, such as the use of coprecipitation and solid dispersion. The authors prepared a different ratio of nifedipine-PVP system by roller mixing method, compared with the co-precipitation method and physical mixing method dissolution rate. The water solubility of nifedipine was 8.25 μg / ml (25 ° C) and the average crystal grain size was about 16 μm. The authors studied the different models and the ratio of PVP and drug roller mix