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以小鼠菌血症模型对抗核心糖脂域ＭｃＡｂ（ＥＬ１、ＥＬ３和３Ｈ４）的免疫保护的效果进行了研究。结果表明，（１）３株ＭｃＡｂ能显著提高受Ｅ．ｃｏｌｉ攻击小鼠的存活率（Ｐ＜０．０５）；（２）ＥＬ３和３Ｈ４还分别有降低３ＬＤ５０绿脓杆菌和５ＬＤ５０鼠伤寒沙门氏菌感染小鼠病死率的作用（Ｐ＜０．０５）；（３）ＥＬ３与３Ｈ４对受５ＬＤ５０Ｅ．ｃｏｌｉ和１０ＬＤ５０绿脓杆菌攻击小鼠有一定的协同保护作用；（４）在ＥＬ１预防性保护试验中发现，提前４周注入ＥＬ１，并于攻菌前１周加强一次，ＥＬ１可明显提高５ＬＤ５０Ｅ．ｃｏｌｉＪ５株攻击小鼠的存活率（Ｐ＜０．０５）。提示ＥＬ３和３Ｈ４对细菌感染小鼠具有一定的交叉保护作用。
The protective effect against core glycolipid-domain McAbs (EL1, EL3 and 3H4) was studied in a mouse bacteremia model. The results showed that (1) 3 McAbs could be significantly enhanced by E. coli. (P <0.05); (2) EL3 and 3H4 also decreased the mortality of mice infected with Salmonella typhimurium 3LD50 and 5LD50 respectively (P <0.05); ( 3) EL3 and 3H4 on 5LD50E. coli and 10LD50 Pseudomonas aeruginosa challenge mice have a synergistic protective effect; (4) EL1 prophylactic protective test found that 4 weeks in advance injection of EL1, and 1 week before the attack bacteria to strengthen, EL1 can significantly improve 5LD50E. Survival rate of E. coli J5 challenge mice (P <0.05). Tip EL3 and 3H4 bacterial infection in mice has some cross-protection effect.