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对40例危重新生儿和20例对照组新生儿血清皮质醇测定。对照组浓度为285±113nmol/L。危重组为942±563nmol/L。29/40高于对照组(?)+2SD。两组有显著差异(P<0.01)。40例中治愈好转20例,恶化死亡14例,前者血清皮质醇为730±455nmol/L。后者为1337±545nmol/L。两组比较差异显著(P<0.01)。病情越重皮质醇浓度越高,预后越差。本文说明新生儿下丘脑-垂体-肾上腺皮质轴调节功能已存在。对毒素、缺氧、感染等刺激反应良好。外源性糖皮质激素能抑制肾上腺皮质。故危重新生儿应慎用皮质激素。
Serum cortisol in 40 critically ill newborns and 20 controls. The control group concentration of 285 ± 113nmol / L. The critically ill group was 942 ± 563 nmol / L. 29/40 higher than the control group (?) +2 SD. There was significant difference between the two groups (P <0.01). In 40 cases, 20 cases were cured and 14 cases were deteriorated. The former serum cortisol was 730 ± 455nmol / L. The latter was 1337 ± 545 nmol / L. The difference between the two groups was significant (P <0.01). The more severe the higher the concentration of cortisol, the worse the prognosis. This article shows that neonatal hypothalamic-pituitary-adrenal axis regulation function already exists. Toxin, hypoxia, infection and other stimuli responded well. Exogenous glucocorticoids can inhibit the adrenal cortex. Therefore, critically ill newborns should be cautious of corticosteroids.