高迁移率族蛋白(HMG)于1973年首次在牛胸腺中被提取和鉴定,因其分子量小在聚丙烯酰胺凝胶电泳中迁移率快而得名,是一类广泛分布于高等真核生物细胞核内的非组DNA结合蛋白。大量文献报道,其家族成员之一的HMGB1在炎症性疾病的发病机制中发挥重要作用。本文对近来HMGB1在心血管系 High mobility group protein (HMG) was extracted and identified in bovine thymus for the first time in 1973. Because of its low molecular weight, its mobility is named after polyacrylamide gel electrophoresis, which is a kind of widely distributed in higher eukaryotes Non-DNA-binding proteins in the nucleus. A large number of literatures reported that HMGB1, one of its family members, plays an important role in the pathogenesis of inflammatory diseases. This article on the recent HMGB1 in the cardiovascular system