论文部分内容阅读
目的探讨高频震荡通气联合肺表面活性物质对新生儿呼吸窘迫综合征的治疗效果。方法选择本院2011年2月—2015年2月收治的120例新生儿呼吸窘迫综合征患儿为研究对象,随机分为对照组和观察组各60例,对照组使用常频振荡通气联合肺表面活性物质治疗,观察组实施高频震荡通气联合肺表面活性物质治疗,比较两组患儿的治疗效果。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果两组患儿治疗后动脉血氧分压(arterial partial pressure of oxygen,Pa O)[(62.362±15.96)、(53.31±13.57)mm Hg(1 mm Hg=0.133 k Pa)]、氧合指数(oxygenation index,OI)[(4.65±2.31)、(7.86±4.26)mm Hg]、动脉/肺泡血氧分压比值(artery/alveolus pulmonis partial pressure of blood oxygen,a/A PO2)[(0.32±0.12)、(0.23±0.11)]比较,差异均有统计学意义(均P<0.05)。观察组患儿治疗后出现肺部感染、肺气漏、肺出血等并发症发生率为11.67%(7/60),对照组为26.67%(16/60),两组患儿并发症发生率比较差异有统计学意义(χ2=4.357,P<0.05)。结论新生儿呼吸窘迫综合征患儿实施高频震荡通气联合肺表面活性物质治疗,疗效显著,能促进病情改善,安全性高,值得推广。
Objective To investigate the therapeutic effect of high frequency oscillatory ventilation combined with pulmonary surfactant on neonatal respiratory distress syndrome. Methods A total of 120 neonates with respiratory distress syndrome admitted from February 2011 to February 2015 in our hospital were selected and randomly divided into control group and observation group, 60 cases in each group. The control group was treated with frequent-frequency oscillatory ventilation combined with lung Surfactant treatment, observation group implementation of high frequency oscillatory ventilation combined with pulmonary surfactant treatment, the treatment effect of two groups of children were compared. Measurement data were compared using t test, count data were compared using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the arterial partial pressure of oxygen (PaO) [(62.362 ± 15.96), (53.31 ± 13.57) mm Hg (1 mm Hg = 0.133 kPa)], oxygenation index (OI) [(4.65 ± 2.31), (7.86 ± 4.26) mm Hg], arterial / alveolus pulmonis partial pressure of blood oxygen (a / A PO2) [(0.32 ± 0.12), (0.23 ± 0.11)], the difference was statistically significant (all P <0.05). The incidence of pulmonary infection, pulmonary leakage and pulmonary hemorrhage in the observation group was 11.67% (7/60) and 26.67% (16/60) in the control group, respectively. The incidence of complications in both groups The difference was statistically significant (χ2 = 4.357, P <0.05). Conclusion Neonatal respiratory distress syndrome in children with high-frequency oscillatory ventilation combined with pulmonary surfactant treatment, significant effect, can improve the condition, high safety, it is worth promoting.