目的:研究羟丙基-β-环糊精对二氢杨梅素(DMY)的增溶作用。方法:采用相溶解度法研究不同温度下羟丙基-β-环糊精对二氢杨梅素的包合作用,HPLC测定二氢杨梅素含量。结果:溶液中DMY与HP-β-CD质量浓度呈线性相关,相溶解度曲线呈AL型,包合物中DMY与HP-β-CD物质的量比1∶1,于25,35,45℃下表观稳定常数分别为500.0,944.8,2 449.8mol.L-1。结论:HP-β-CD对DMY有较好的增溶作用。 Objective: To study the solubilization of dihydromyricetin (DMY) by hydroxypropyl-β-cyclodextrin. Methods: Inclusion of DHM at different temperatures was studied by phase solubility method, and the content of DHM was determined by HPLC. Results: The linear relationship between the concentration of DMY and HP-β-CD in the solution was obtained. The phase solubility curve showed AL type. The ratio of DMY to HP-β-CD in the inclusion complex was 1: 1 at 25, Under the apparent stability constants were 500.0,944.8,2 449.8mol.L-1. Conclusion: HP-β-CD has better DMY solubilization effect.