论文部分内容阅读
目的分析卵巢上皮癌不同分期及治疗方案的疗效。方法对汕头大学医学院附属肿瘤医院81例卵巢上皮癌按FIGO分期及两种不同治疗方案的生存情况和副作用进行对比研究,采用Kaplan-Meier方法进行生存分析。结果早期生存率为95.7%,晚期生存率为62.1%,早期生存率显著高于晚期(P=0.006);TP方案与CP方案的生存率分别为89.1%和59.5%,TP方案高于CP方案,但两者生存率比较差异无统计学意义(P>0.05),两组方案骨髓抑制及消化道反应的毒副作用无明显差异,TP方案出现Ⅰ、Ⅱ度手足麻木并发症;脂质体紫杉醇加卡铂对腹膜后淋巴结转移有较好化疗效果。结论早期诊治是提高卵巢上皮癌生存率的关键,TP方案和CP方案均为目前有效治疗卵巢上皮癌的可选择方案,具有靶向作用的脂质体紫杉醇联合铂类药物对腹膜后转移淋巴结可能有较好的疗效。
Objective To analyze the effect of different stages and treatment of ovarian epithelial carcinoma. Methods Survival and side effects of FIGO staging and two different treatment regimens were compared between 81 cases of ovarian epithelial cancer affiliated to Cancer Hospital of Shantou University Medical College and Kaplan-Meier method. Results The early survival rate was 95.7%, the late survival rate was 62.1%, and the early survival rate was significantly higher than that in the late stage (P = 0.006). The survival rates of TP regimen and CP regimen were 89.1% and 59.5%, respectively, and TP regimen was higher than CP regimen , But there was no significant difference in the survival rates between the two groups (P> 0.05). There was no significant difference between the two groups in the side effects of myelosuppression and gastrointestinal reactions. The complications of numbness of hand and foot were observed in TP regimen. Gacarboplatin on retroperitoneal lymph node metastasis has better chemotherapeutic effect. Conclusion Early diagnosis and treatment is the key to improve the survival rate of ovarian epithelial cancer. Both TP and CP regimens are the effective alternatives for the treatment of epithelial ovarian cancer. Targeted liposomal paclitaxel combined with platinum can inhibit the metastasis of retroperitoneal lymph nodes Have a good effect.