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目的:探讨侵袭性鼻脑毛霉菌病的诊断、病程与综合治疗手段。方法:回顾分析5例侵袭性鼻脑毛霉菌病的临床资料,从患者的病程进展分析该病的临床特征以及诊断与治疗方法;从不同的治疗方法所获得的疗效中获取较佳综合性治疗手段的选择。结果:1例在发病后3周内死亡,3例生存2个月~2年,1例存活至今已3年,本组总体死亡率80%。结论:侵袭性鼻脑毛霉菌病是继发于全身免疫状态低下的严重疾病,病情进展迅速,病变累及眼眶和颅内,死亡率高。早期手术清理病灶、去除真菌生长环境、配合全身综合治疗可延缓病程进展。经鼻内镜手术可以达到清除鼻窦-眶内-颅内病变组织的目的。
Objective: To investigate the diagnosis, course of disease and comprehensive treatment of invasive nasal mucormycosis. Methods: The clinical data of 5 cases of invasive nasal mucormycosis were retrospectively analyzed. The clinical features, diagnosis and treatment of the disease were analyzed according to the patient’s course of disease. The best comprehensive treatment was obtained from the curative effect of different treatments Means of choice. Results: One patient died within 3 weeks after onset and 3 patients survived for 2 months to 2 years. One patient survived for 3 years and the overall mortality rate in this group was 80%. Conclusions: Invader nasal mucormycosis is a serious disease secondary to lower immune status. The disease progresses rapidly and the lesions involve the orbit and the brain. The mortality rate is high. Early surgical removal of lesions, removal of fungal growth environment, combined with general treatment can delay the course of progress. Nasal endoscopic surgery can achieve the purpose of removal of sinus - orbital - intracranial lesions.