前言肺水肿的研究虽已有二百年的历史,但其发生机制至今尚未充分阐明。尤其是体液因子参与其发病过程的研究则更为不足。自从5-羟色胺(以下简称5-HT)之被发现及共生理功能与药理作用的广泛研究以来,已经证明5-HT能引起毛细血管通透性的增高。并且5-HT可能参与某些类型的水肿过程,如类过敏反应的水肿与大鼠急性松节油性胸膜炎的渗出过 Although the study of pulmonary edema has two hundred years of history, its mechanism has not yet been fully elucidated. In particular, humoral factors involved in the pathogenesis of the study is more inadequate. 5-HT has been shown to cause an increase in capillary permeability since extensive research into the discovery of 5-hydroxytryptamine (hereinafter referred to as 5-HT) and its symbiotic physiological and pharmacological effects has been shown. And 5-HT may be involved in some types of edema process, such as anaphylactoid edema and acute exudate in rats with exudative pleurisy