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目的探讨慢性心力衰竭(CHF)患儿血清甲状腺激素(TH)水平的变化状态及其临床意义。方法采用化学发光免疫法测定36例CHF患儿(CHF组)和32例非CHF患儿(对照组)血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺素(TSH)的水平并比较;并对心衰患儿心功能改善前后的血清甲状腺素水平进行比较。结果 (1)CHF组与对照组比较,血清T3、T4、FT3均降低(P<0.05或P<0.01),FT4、TSH无明显变化(P>0.05);(2)T3、T4、FT3随心衰程度加重逐渐降低(P<0.01)。结论 CHF组患儿血清T3、T4、FT3水平显著下降,并与心力衰竭严重程度相关。
Objective To investigate the changes of serum thyroid hormone (TH) in children with chronic heart failure (CHF) and its clinical significance. Methods Serum levels of triiodothyronine (T3), thyroxine (T4), free triiodothyronine (LDH) and triamcinolone acetonide were determined by chemiluminescence immunoassay in 36 children with CHF (CHF group) and 32 children without CHF (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were compared between the two groups. The levels of serum thyroxine before and after heart function improvement were compared between two groups. Results (1) The levels of T3, T4 and FT3 in CHF group were lower than those in control group (P <0.05 or P <0.01), but there was no significant change in FT4 and TSH (P> 0.05) Heart failure worsened gradually (P <0.01). Conclusion Serum levels of T3, T4 and FT3 in children with CHF decreased significantly, which were correlated with the severity of heart failure.