论文部分内容阅读
近20年来尽管对间变星型细胞瘤和多型性成胶质细胞瘤的治疗作了极大的努力,但预后仍不令人满意。近来最有效的治疗方案是:手术切除肿瘤继之放疗和用亚硝基脲类药化疗。为了改善药物进入肿瘤同时减少全身毒性,一些作者建议作动脉内灌注。通过动脉内灌注卡氮芥(BCNU)的局部毒性大,其临床结果令人失望。本研究使用氯乙亚硝基脲(HECNU)作动脉内灌注,病人对其的耐受性较对BCNU的为好。病人及方法:40例患者均经组织学证实为恶性胶质瘤。其中多型性成胶质细胞瘤33例,间变星型细胞瘤6例和间变少突神经胶质瘤1例。37例在术后一月内接受动脉内灌注化疗。3例延迟至术后3个月。首次治疗前行血管造影排除重要血管动脉粥
Despite the tremendous efforts made in the treatment of metaplastic astrocytoma and glioblastoma multiforme for the past two decades, the prognosis remains unsatisfactory. Recently the most effective treatment options are: Surgical resection of tumors followed by radiotherapy and chemotherapy with nitrosoureas. To improve drug entry into the tumor while reducing systemic toxicity, some authors recommend intra-arterial infusion. The clinical consequences of disappointing local toxicity through intra-arterial infusion of BCNU. In our study, intravenous infusion of nitrocein nitrosourea (HECNU) was used for intra-arterial instillation, and patients were more tolerant than BCNU. Patients and Methods: Forty patients were histologically confirmed as malignant gliomas. Among them, there were 33 cases of glioblastoma multiforme, 6 cases of metaplastic astrocytoma and 1 case of anaplastic oligodendroglioma. Thirty-seven patients underwent intra-arterial infusion chemotherapy within one month after surgery. 3 cases delayed to 3 months after surgery. The first treatment before angiography exclude important vascular atheroma