百日咳、白喉、破伤风3种急性传染病对人体危害很大,特别是对婴幼儿和10岁以下儿童危害尤甚,可造成发育迟缓、智力障碍,甚至死亡。临床研究发现,全菌体百白破联合疫苗(DTwP)虽然免疫效果尚可,但因其存在极少见较严重不良反应,一定程度上影响免疫儿童与家长的接受度[1]。20世纪8 Pertussis, diphtheria, tetanus three kinds of acute infectious diseases on the human body is very large, especially for infants and children under the age of 10 particularly dangerous, can cause stunting, mental retardation and even death. Clinical studies have found that all-bacteria DTTP vaccine (DTwP) although the immune effect is acceptable, but because of its very rare and serious adverse reactions, to a certain extent, affect the immunization of children and parents acceptance [1]. 20th century 8