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目的动态监测创伤脓毒症及非脓毒症血浆中HMGB-1、IL-13、IL-17的量,初步探究创伤脓毒症发生发展中部分细胞因子的作用,为临床治疗提供依据。方法将江苏大学附属武进医院2013-10-2015-10收治的28例患者及体检中心健康人群为研究对象。分为创伤脓毒症组、创伤非脓毒症组。其中创伤脓毒症组14例、创伤非脓毒症组14例及正常对照组20例。用酶联免疫分析法测其血浆中HMGB-1、IL-13、IL-17的量。结果:HMGB-1、IL-13、IL-17的含量与对照组比较,在创伤脓毒症组及创伤非脓毒症组均明显升高(P<0.05);在创伤脓毒症组,与创伤非脓毒症组比较HMGB-1和IL-1的含量明显升高(P<0.05),而IL-17含量并没有显著提高,且各组组内各时间点件没有显著差异。结论HMGB-1、IL-17,IL-13含量在创伤脓毒症的病情演变中都起着重要的作用。及时监测HMGB-1、IL-13的变化,可更敏感地判断创伤脓毒症的发生,评估其严重程度,为临床治疗提供依据。
Objective To dynamically monitor the levels of HMGB-1, IL-13 and IL-17 in sepsis and non-sepsis-induced sepsis and to explore the role of some cytokines in the development of septic sepsis and provide a basis for clinical treatment. Methods 28 patients admitted to Wujin Hospital affiliated to Jiangsu University from October 2013 to October 2015 were enrolled in this study. Divided into traumatic sepsis group, trauma non-sepsis group. Among them, 14 were traumatic sepsis, 14 were traumatic non-sepsis and 20 were normal control. Plasma levels of HMGB-1, IL-13 and IL-17 were measured by enzyme-linked immunosorbent assay. Results: Compared with the control group, the levels of HMGB-1, IL-13 and IL-17 in trauma sepsis group and trauma non-sepsis group were significantly increased (P <0.05). In traumatic sepsis group, The levels of HMGB-1 and IL-1 were significantly increased (P <0.05), while the content of IL-17 was not significantly increased in trauma and non-sepsis groups, and there was no significant difference in each time point in each group. Conclusion The contents of HMGB-1, IL-17 and IL-13 play an important role in the development of sepsis. Timely monitoring the changes of HMGB-1, IL-13 can be more sensitive to determine the occurrence of traumatic sepsis, assess the severity, provide the basis for clinical treatment.