论文部分内容阅读
目的：探讨生长抑素（ｓｏｍ ａｔｏｓｔａｔｉｎ， Ｓ Ｓ）及氧化苦参碱（ｏｘｙｍ ａｔｒｉｎｅ， Ｏｘｙ）对大鼠急性胰腺炎（ Ａ Ｐ）的治疗作用及其机制。方法： 由蛙皮素皮下注射诱导大鼠 Ａ Ｐ，随后予静脉输注 Ｓ Ｓ及腹腔内注射 Ｏｘｙ。结果： 与 Ａ Ｐ组相比， Ｓ Ｓ及 Ｏｘｙ 治疗组大鼠胰腺／体质量值明显下降，血清淀粉酶及胰腺组织病理学改变明显改善， 血清及胰腺组织内 Ｉ Ｌ１、 Ｉ Ｌ６、 Ｔ Ｎ Ｆα等炎性细胞因子水平显著降低（均 Ｐ＜ ０．０１）。结论： Ｓ Ｓ及 Ｏｘｙ 对实验性大鼠 Ａ Ｐ具有良好治疗效果，其机制可能与其抑制炎性细胞因子的产生有关。
Objective: To investigate the therapeutic effect of som atostatin (Ss) and oxymatrine (Oxy) on acute pancreatitis (AP) in rats and its mechanism. Methods: Subcutaneous injection of bombesin induced AP in rats, followed by intravenous infusion of S S and intraperitoneal injection of Oxy. Results: Compared with A P group, the pancreas / body mass of rats in S S and Oxy treatment groups decreased significantly, the pathological changes of serum amylase and pancreatic tissue were significantly improved, the levels of I L1 and I Lin serum and pancreas 6, T N Fα and other inflammatory cytokines levels were significantly lower (P <0.01). Conclusion: S S and Oxy have a good therapeutic effect on A P in experimental rats, which may be related to the inhibition of the production of inflammatory cytokines.