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目的:观察凯时(前列腺素E1脂微球载体制剂)对合并有慢性肾功能不全的心脏病患者,心脏手术后肾功能的保护疗效。方法:36例合并慢性肾功能不全的心脏手术患者,随机分为对照组(17例)和凯时治疗组(19例),治疗组在与对照组的基础治疗相同的基础上给予凯时20μg,2次/d静脉注射,连续应用1周。结果:治疗组患者的血BUN及Cr显著低于对照组,尿量明显多于对照组。结论:凯时可以有效降低合并有慢性肾功能不全的患者心脏手术围术期血BUN、Cr,增加尿量,从而延缓甚至避免了透析治疗。
OBJECTIVE: To observe the protective effect of Kay (prostaglandin E1 lipid microsphere carrier preparation) on cardiac function after heart surgery in patients with heart disease complicated with chronic renal insufficiency. Methods: Thirty-six patients undergoing cardiac surgery with chronic renal insufficiency were randomly divided into control group (17 cases) and Kai-Shi treatment group (19 cases). The treatment group was treated with Kai 20μg on the same basis as the control group , 2 times / d intravenous injection, continuous application for 1 week. Results: The BUN and Cr levels in the treated group were significantly lower than those in the control group, and the urine output was significantly more than that in the control group. Conclusions: When the Kai time can effectively reduce the perioperative blood BUN, Cr in patients with chronic renal insufficiency, increase urine output, thus delay or even avoid the dialysis treatment.