自噬是细胞通过自我消化实现大分子物质的循环再利用,维持细胞自身稳定的生物学过程。自噬活性的变化、自噬性细胞死亡与恶性肿瘤的发生、发展有关。自噬相关基因ARHI通过调节自噬活性,在肿瘤的发生、发展中发挥作用。ARHI调节自噬信号通路中某些关键激酶可能为肿瘤的治疗提供新的药物作用靶点。 Autophagy is the cell through self-digestion to achieve recycling of macromolecular substances, to maintain the cell’s own stable biological processes. Changes in autophagy activity, autophagic cell death and the occurrence and development of malignant tumors. Autophagy-related gene ARHI plays a role in tumorigenesis and development by regulating the activity of autophagy. ARHI regulates some key kinases in autophagy signaling pathway and may provide a new drug target for tumor therapy.