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探讨原发性肺癌和肺组织雌激素受体（ＥＲ）和孕激素受体（ＰＲ）的表达和意义。方法应用荧光组织化学法测定两种受体。结果肺癌ＥＲ阳性２３．８％（１０／４２），ＰＲ阳性２８．６（１２／４２）；胚胎肺ＥＲ、ＰＲ阳性率男胚均为３０％，女胚均为４０％；非肿瘤肺ＥＲ、ＰＲ全部阴性。肺癌组中，ＥＲ、ＰＲ阳性肿瘤以鳞癌为主；组织分化好其ＥＲ受体有阳性表达倾向，低分化癌及小细胞癌表达倾向阴性。结论与乳癌相似，肺癌中ＰＲ是雌激素诱导合成的蛋白质和反映功能性ＥＲ的标记物；ＥＲ、ＰＲ表达在一定程度上反映癌的分化程度，分化好的癌ＥＲ和ＰＲ阳性率高；ＥＲ和ＰＲ阳性的肺癌为激素依赖性肿瘤，与雌激素靶器官的恶性肿瘤一致，可试用内分泌治疗
To investigate the expression and significance of estrogen receptor (ER) and progesterone receptor (PR) in primary lung cancer and lung tissue. Methods Two receptors were measured by fluorescent histochemistry. Results The positive rate of ER in lung cancer was 23.8% (10/42), and the positive rate of PR was 28.6(12/42). The positive rates of ER and PR in embryonic lung were 30% for males and 40% for female embryos. Non-tumor lung ER All PRs are negative. In the lung cancer group, the ER and PR positive tumors were mainly squamous cell carcinoma. The ER receptors were positive for the tissue differentiation, and the poorly differentiated and small cell carcinomas were negative for the expression. Conclusion Similar to breast cancer, PR in lung cancer is an estrogen-induced synthetic protein and a marker reflecting functional ER; ER, PR expression reflects the degree of differentiation of cancer to some extent, and the positive rate of ER and PR in well-differentiated cancer is high; ER And PR-positive lung cancer is a hormone-dependent tumor, consistent with the malignant tumors of estrogen target organs, and endocrine therapy can be tried