组胺能显著地抑制正常人外周血单个核细胞(PBMC)对美洲商陆(PWM)的增生反应和IgG生成,但对活动性系统性红斑狼疮(SLE)患者的抑制作用明显低于对正常人的作用(P<0.01)。组胺所诱导的抑制因子(HSF)也有上述抑制作用。西米替丁和消炎痛均能阻断HSF的生成,提示表达组胺2型受体(H_2R)的细胞以及PGE_2与HSF生成有关。值得注意的是活动性SLE患者的HSF生成能力显著低于正常人的能力(P<0.01),而且患者PBMC对正常人HSF的反应性显著低下,提示活动性SLE患者的“抑制性”T细胞功能低下。 Histamine significantly inhibited the proliferation and IgG production of normal human peripheral blood mononuclear cells (PBMCs) against Pulsatilla chinensis, but significantly lower the inhibitory effect on patients with active systemic lupus erythematosus (SLE) Human effects (P <0.01). Histamine induced inhibitors (HSF) also have the above inhibitory effect. Both cimetidine and indomethacin blocked HSF production, suggesting that cells expressing histamine 2 receptor (H_2R) and PGE_2 are involved in HSF production. It is noteworthy that HSF-producing ability of patients with active SLE was significantly lower than that of normal people (P <0.01), and the responsiveness of PBMC to normal human HSF was significantly lower, suggesting that “inhibitory” T cells in patients with active SLE Low function.