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目的：观察中国上海与荷兰阿姆斯特丹两地幽门螺杆菌（H．pylori）感染性胃炎患者胃窦部粘膜萎缩与肠化的发生率及发生年龄的差异。方法：功能性消化不良伴H.pylori感染的上海患者265例和阿姆斯特丹患者261例纳入研究。根据新悉尼分类法对患者治疗前胃窦粘膜标本的萎缩和肠化程度进行分级。结果：阿姆斯特丹患者的萎缩与肠化发生率（42％和26％）低于上海患者（52％和32％），但仅萎缩的差异有统计学意义（P=0.028）。两地患者的萎缩和肠化均以轻、中度居多，重度萎缩和肠化少见。两地伴萎缩和肠化患者的平均年龄（上海：42．12岁±9.80岁和42．56岁±9．96岁；阿姆斯特丹：55．16岁±12．20岁和57．79岁±11．13岁）明显高于不伴萎缩和肠化者（上海：39．71岁±1016岁和4019岁±9.99岁；阿姆斯特丹：45.70岁±12.44岁和46．89岁±12.68岁）。萎缩和肠化的发生率均随年龄增长而增加，50岁以后两地患者萎缩和肠化的发生率接近相等，超过60岁时达到高峰，但上海患者萎缩与肠化的发生较早且较重。结论：H.yylori感染性胃炎的病理变化中萎缩和肠化的发生率有地理性差异。上海患者的萎缩和肠化发生较早且较严重，推测这可能与我同患者H.pylori感染年龄轻和感染程度重有关。
Objective: To observe the incidence and age of atrophic mucosa atrophy and intestinal metaplasia in patients with H.pylori-infecting gastritis between Shanghai, China and Amsterdam, the Netherlands. METHODS: Two hundred and sixty-two Shanghai patients with functional dyspepsia with H. pylori infection and 261 patients with Amsterdam were included in the study. The atrophy and intestinal metaplasia of patients with antral gastric mucosa before treatment were graded according to the new Sydney classification. RESULTS: The prevalence of atrophy and intestinal metaplasia in Amsterdam was lower (42% vs 26%) than in Shanghai (52% vs 32%), but the only difference was statistically significant (P = 0.028). Both patients with atrophy and intestinal metaplasia are mild, moderate majority, severe atrophy and intestinal metaplasia rare. Average age of patients with atrophy and intestinal metaplasia (Shanghai: 42.12 years ± 9.80 years and 42.56 years ± 9.96 years; Amsterdam: 55.16 years ± 12.20 years and 57.79 years ± 11 .13 years) was significantly higher than those without atrophy and intestinal metaplasia (Shanghai: 39.71 years ± 1016 years and 4019 years ± 9.99 years; Amsterdam: 45.70 years ± 12.44 years and 46.89 years ± 12.68 years). The incidence of atrophy and intestinal metaplasia increased with age, and the incidence of atrophy and intestinal metaplasia in patients after 50 years of age was similar, reaching the peak after 60 years of age, but the incidence of atrophy and intestinal metaplasia in Shanghai patients was earlier than weight. Conclusions: The incidence of atrophy and intestinal metaplasia in pathological changes of H.yylori-infected gastritis has geographical differences. Shanghai patients with atrophy and intestinal metaplasia occurred earlier and more serious, speculated that this may be with my patients with H.pylori infection age and severity of infection related.