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本文报导了氯霉素在大鼠生后7天内和鼠龄60天时给药对其成熟后的睡眠、主动回避反应以及电休克阈的影响。在新生期给药组,快眼动睡眠量显著减少,但主动回避反应成绩没有明显变化.在鼠龄60天给药组,动物的快眼动睡眠量和主动回避反应成绩均明显降低,电休克阈也降低。文中讨论了氯霉素对快眼动睡眠和脑发育的影响以及发育期快眼动睡眠与脑发育的关系。
This article reports the effect of chloramphenicol on its sleep, active avoidance and electrical shock thresholds within 7 days and 60 days after birth in rats. In the neonatal administration group, the amount of REM sleep decreased significantly, but the active avoidance reaction did not change significantly.At the age of 60 days, the fasting sleep volume and active avoidance response of animals decreased significantly Shock threshold is also reduced. The paper discusses the impact of chloramphenicol on fast eye movement sleep and brain development as well as the relationship between fast eye movement sleep and brain development in developmental period.