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目的探讨IL-1β基因多态性、幽门螺旋杆菌(Helicobacter pylori,HP)感染及其交互作用与新疆汉族胃癌发生的关系。方法采用Snapshot技术分析229例胃癌患者和作为对照的256例非胃癌患者IL-1β基因rs1143633、rs3136558和rs1143630位点基因型的分布;采用幽门螺旋杆菌IgG抗体检测试剂盒检测研究对象Hp感染率。结果 IL-1β基因rs3136558位点多态性、Hp感染与新疆汉族胃癌的发病有关;Hp感染与基因之间的交互作用表明,在汉族人群中,Hp感染阳性,同时携带IL-1β基因rs3136558 TT基因型个体发生胃癌的危险性是Hp感染阴性并携带IL-1β基因rs3136558 CT+CC基因型个体的2.25倍(95%CI:1.37～3.69)。结论 Hp感染和IL-1β基因多态之间存在着交互作用,共同促进胃癌的发生。
Objective To investigate the relationship between IL-1β gene polymorphism, Helicobacter pylori (HP) infection and its interaction with gastric carcinogenesis in Han nationality in Xinjiang. Methods The genotype distributions of rs1143633, rs3136558 and rs1143630 of IL-1β gene in 229 gastric cancer patients and 256 non-gastric cancer patients as controls were analyzed by Snapshot technique. The prevalence of Hp infection was determined by using the Helicobacter pylori IgG antibody test kit. Results The rs3136558 polymorphism of IL-1β gene and Hp infection were related to the pathogenesis of gastric cancer in Xinjiang Han. The interaction between Hp infection and the genes showed that Hp infection was positive in Han population, and at the same time, the IL-1β gene rs3136558 TT The risk of developing gastric cancer in genotype individuals was 2.25-fold (95% CI: 1.37 to 3.69) for Hp-negative individuals carrying the rs3136558 CT + CC genotype of the IL-1β gene. Conclusion There is an interaction between Hp infection and IL-1β gene polymorphism to promote gastric cancer.