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目的:探讨蒙药验方制剂琪笋·德密格-4胶囊(QD-4)的药理作用。方法:采用高脂饲料诱发新西兰兔高脂血症动脉硬化模型;高营养饲料诱发SD大鼠单纯性肥胖模型,受试药分3个剂量组,分别预防性给予QD-4(兔:0.75,0.37,0.19g·kg-1;大鼠:3.24,1.62,0.81 g·kg-1)与模型对照组、阳性药(兔:辛伐他汀0.5 mg·kg-1;大鼠:亚油酸0.39 g·kg-1)对照组和空白组,ig给药,连续8周。检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量和肥胖指标,观察分析主动脉粥样硬化斑块,以评价QD-4调脂、减肥作用。结果:QD-4显著降低单纯性肥胖模型SD大鼠血清TG(P<0.01),升高HDL-C(P<0.05),抑制实验鼠体重(P<0.01),缩小鼠体长,增加尾长(P<0.05),抑制脂肪细胞增长(P<0.01),作用强度优于亚油酸,但实验鼠摄食量无差别,对TC和LDL-C的影响不及亚油酸;能降低高脂动脉粥样硬化症模型新西兰兔血清TC、LDL-C(P<0.01～0.05),不同程度地减轻、减少实验兔主动脉粥样硬化程度,影响程度与辛伐他汀组相当,其他指标未显统计意义。实验显示量效关系明显,低剂量组作用不理想。结论:蒙药琪笋·德密格-4胶囊具有调脂、减肥及抗动脉粥样硬化作用,符合蒙医升清降浊,消减“巴达干”理论。
Objective: To investigate the pharmacological effects of Mongolian prescription prescription QDD-4 capsules (QD-4). Methods: The model of atherosclerosis in rabbits with hyperlipidemia was induced by high-fat diet. The model of simple obesity induced by high-nutrition diet was divided into three groups: QD-4 (rabbit: 0.75, 0.37 and 0.19 g · kg-1 respectively; rats: 3.24, 1.62 and 0.81 g · kg-1) were compared with the model control group and the positive drug (rabbit: simvastatin 0.5 mg · kg- g · kg -1) control group and blank group, ig administration for 8 weeks. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and obesity indices were measured. Aortic atherosclerotic plaque , To evaluate QD-4 lipid-lowering, weight loss. Results: QD-4 significantly decreased serum TG (P <0.01), HDL-C (P <0.05), inhibited body weight (P <0.01), reduced body length and increased tail length (P <0.05), inhibit the growth of adipocytes (P <0.01), and the effect strength was better than that of linoleic acid. However, there was no difference in the food intake between experimental rats and TCL and LDL-C, Atherosclerosis model of New Zealand rabbit serum TC, LDL-C (P <0.01 ~ 0.05), to varying degrees, reduce the degree of atherosclerosis in experimental rabbits, the impact of simvastatin group was the same, the other indicators were not significantly Statistical significance. Experiments show that the dose-response relationship is obvious, the effect of low-dose group is not ideal. Conclusion: The Mongolian medicine Baijian · Demi Ge-4 capsules have lipid-lowering, weight-loss and anti-atherosclerotic effects, in line with Mongolian Shengqing Jiang, eliminating “Bada dry ” theory.