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目的将鸡胚绒毛尿囊膜血管试验(CAMVA)与家兔眼刺激试验进行比较,探讨在化妆品安全性评价中的应用。方法将11种化妆品原料和8种化妆产品分别进行鸡胚绒毛尿囊膜血管试验和家兔眼刺激试验,结果进行分析比较。结果 CAMVA试验分级标准和动物试验评级标准具有较高的等级相关性和一致性。结论 CAMVA是一种较好的体外眼刺激替代方法,但需和其他体外试验组合评价更加可靠。
Objective To compare chick embryo chorioallantoic membrane vascular test (CAMVA) with rabbit eye irritation test to explore the application in cosmetic safety evaluation. Methods 11 kinds of cosmetic raw materials and 8 kinds of cosmetic products were chick chorioallantoic vascular test and rabbit eye irritation test results were analyzed and compared. Results The CAMVA test grading standards and animal testing grading standards have a higher level of correlation and consistency. Conclusions CAMVA is a good alternative method for ophthalmic stimulation in vitro, but it needs to be combined with other in vitro tests to evaluate more reliable.