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目的:探讨窒息新生儿出生早期胱抑素C(CysC)的连续性变化及其临床意义。方法:选用佛山市妇幼保健院收治的86名窒息新生儿作为观察对象,并以30名非窒息患儿为对照组,于生后各时段分别监测CysC。结果:3组患儿各时段监测CycC水平,可见各组间CycC水平变化差异有统计学意义(F=3.58,P=0.01);对照组的各个时段的CycC水平差异无统计学意义(P>0.05),其他组别患儿各个时段的CycC水平差异有统计学意义。结论:窒息新生儿生后早期CycC水平的变化不同于非窒息新生儿,且改变的程度也与窒息程度的不同有关,可早期发现肾损伤,并作为监测肾功能恢复的有效指标,利于指导临床进行有效治疗。
Objective: To investigate the change of cystatin C (CysC) in neonatal asphyxia and its clinical significance. Methods: Eighty-six asphyxial newborns admitted to Foshan MCH hospital were selected as observation objects. Thirty non-asphyxiated children were used as control group, and CysC was monitored in different periods after birth. Results: The CycC levels in each group were monitored at different time points. The changes of CycC in each group were statistically significant (F = 3.58, P = 0.01). There was no significant difference in the CycC levels between the three groups (P> 0.05). There was significant difference in CycC levels between different groups in different periods. CONCLUSIONS: The changes of CycC level in neonates with asphyxia after birth are different from that of non-asphyxiated neonates, and the degree of change is also related to the different degree of asphyxia. Early detection of renal injury can be used as an effective indicator to monitor renal function recovery, Effective treatment.