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目的:观察中西医结合治疗多发性斑秃疗效及远期复发情况。方法:将就诊于医院脱发专病门诊的80例多发性斑秃患者,随机分为中西医结合组和西药组,每组各40例。所有患者常规使用基础性药物治疗:外用5%米诺地尔酊和0.05%丙酸氟替卡松乳膏。西药组予复方甘草酸苷片口服,中西医结合组口服止脱生发汤,连续治疗3个月后,判定临床疗效并进行统计学分析。结果:观察中西医结合组和西药组治疗后的临床疗效,中西医结合组的显效率为75.0%,总有效率为95.0%,西药组的显效率为27.5%,总有效率为77.5%,差异有统计学意义(P<0.05)。中西医结合组进展期和静止期的显效率分别为76.2%,73.7%,西药组进展期和静止期的显效率分别为18.2%,38.9%,进行统计学比较,差异均有统计学意义(P<0.05)。对两组中的痊愈患者随访1年,中西医结合组和西药组的复发率分别为17.6%和80%,两组比较,有统计学差异(P<0.05)。结论:所采用中西医结合治疗多发性斑秃的方法较单纯使用西药的方法可以提高临床疗效,并可以降低远期复发率。在连续治疗的3个月期间,中西医结合组的患者出现药物相关的不良反应少且轻微。本研究采用的中西医结合治疗多发性斑秃的方法值得临床推广使用。
Objective: To observe the curative effect of traditional Chinese and western medicine on the treatment of multiple alopecia areata and long-term relapse. Methods: A total of 80 patients with multiple alopecia areata were randomly divided into two groups, 40 cases in each group. All patients routinely used basic medication: topical 5% minoxidil tincture and 0.05% fluticasone propionate cream. Western medicine group to compound glycyrrhizin tablets orally, Integrative Medicine oral antidebrondering hair soup, continuous treatment for 3 months, to determine the clinical efficacy and statistical analysis. Results: The clinical efficacy of the combination of traditional Chinese and western medicine was observed. The effective rate was 75.0% in the combined traditional Chinese and western medicine group and the total effective rate was 95.0%. The effective rate in the western medicine group was 27.5% and the total effective rate was 77.5% The difference was statistically significant (P <0.05). The effective rates of the advanced and quiescent periods in the combined traditional Chinese and western medicine groups were 76.2% and 73.7%, respectively. The effective rates in the advanced and quiescent periods of the western medicine group were 18.2% and 38.9%, respectively. Statistical differences were statistically significant P <0.05). The follow-up of 1 year in the cured patients in both groups was 17.6% and 80% respectively in the Integrative Medicine Group and Western Medicine Group. There was significant difference between the two groups (P <0.05). Conclusion: The treatment of multiple alopecia areata with traditional Chinese and western medicine method can improve the clinical curative effect and reduce the long-term recurrence rate. During the 3 months of continuous treatment, patients in the Integrative Medicine group experienced fewer and minor drug-related adverse events. In this study, the combination of traditional Chinese and Western medicine treatment of multiple alopecia areata is worthy of clinical promotion.