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本文报道5例患者在应用茚满丙二胺(Aprindine)期间出现尖端扭转型室性心动过速.例1,女,51岁,4年前行主动脉瓣换置术.术中并发下壁心肌梗塞.术后常发生室性心动过速,用奎尼丁和双异丙吡胺治疗引起Q-T间期延长及尖端扭转型室性心动过速发作.其后,改用普鲁卡因酰胺治疗有效,但因引起狼疮样综合征,遂改用口服茚满丙二胺125毫克/日.在入院前一周,有心室颤动发作.入院后心脏监护显示Q-T间期0.6秒,有
In this paper, we report five cases of torsades de pointes (Torsades de pointes) during the application of indindane (Aprindine) .In 1, female, age 51, underwent aortic valve replacement 4 years ago, Myocardial infarction.Postoperative ventricular tachycardia often occurs, with quinidine and bisopalramine treatment led to the QT prolongation and torsades de pointes ventricular tachycardia onset.Second, the use of procainamide Treatment is effective, but due to cause lupus-like syndrome, then switch to oral indane propylenediamine 125 mg / day .A week before admission, ventricular fibrillation attack .Hospitalization after cardiac monitoring showed QT interval of 0.6 seconds, there