论文部分内容阅读
作者在1949年冬建议使用醋酸钾作为制取青霉素钾盐的结晶反应剂,并在同年12月17日试验成功后,将试制经过作了报道。几年来,这一方法经有关的同志们在研究室和实验生产上试用和改进,效果已大为提高——从青霉素有机溶媒提取液直接沉淀结晶的收得率约为70%,运用恒沸蒸馏技术的晶体收得率约达90%。除收得率高于一般方法外,在用料经济和操作的便利和安全方面也证实了用醋酸钾作为青霉素结晶反应剂是适合于青霉素工业生产使用的。为了总结几年来的经验,现在结合各种结晶方法加以比较,提出个人对于青霉素工业生产的认识,并将这一方法作较详的叙述。
In the winter of 1949, the author suggested using potassium acetate as a crystallization reagent for preparing penicillin potassium salt, and after the test was successful on December 17 of the same year, trial production was reported. Over the past few years, this method has been tried and improved by the relevant comrades in the research room and experimental production. The effect has been greatly improved - the yield of direct precipitation of crystals from the penicillin organic solvent extract is about 70%, and constant boiling is used. Distillation technology yields about 90% crystals. In addition to the higher yield than the general method, the use of potassium acetate as a crystallization reagent for penicillin is also proven to be suitable for penicillin industrial production in terms of the economics of use and the convenience and safety of the operation. In order to sum up the experience of the past few years, we now compare the various crystallization methods and propose the individual’s understanding of penicillin industrial production, and make a detailed description of this method.