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某男性患者,58岁,长期服用稳定剂量华法林,后因细菌性脑膜炎入院治疗,入院后戒烟,出院后继续按原来的维持剂量服用华法林,但发现国际标准化比值(INR)开始升高。经仔细询问患者,他表示戒烟后没有其他饮食或生活习惯改变。医师根据其情况,考虑到是戒烟前后INR值有较大变化,因此将其华法林维持剂量适当减少%后,其INR值恢复正常。他才知道,原来吸烟对华法林的给药剂量造成
A male patient, 58 years old, took a steady dose of warfarin over a long period of time and was hospitalized for bacterial meningitis. After admission, he quit smoking and continued to receive warfarin at the original maintenance dose after discharge, but found that the International Normalized Ratio (INR) Rise. After careful interrogation of patients, he said there was no other diet or lifestyle change after quitting smoking. According to the doctor’s condition, considering that there is a large change in INR before and after smoking cessation, the INR value returned to normal after warfarin maintenance dose was appropriately reduced by%. He did not know that the original dose of warfarin was caused by smoking