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目的:探讨新疆维吾尔族宫颈癌新辅助化疗前后P-gp、MRPI和GST-π的表达及其与化疗疗效的关系。方法:运用S-P法分别检测维吾尔族妇女宫颈鳞癌组织22例新辅助化疗前后及正常宫颈组织20例P-gP、MRPI和GST-π的表达水平。结果:①新疆维吾尔族正常宫颈、初治宫颈癌组织中P-gp的阳性表达率分别为10%、40.9%;MRP1的阳性表达率分别为15%、31.8%;GST-π的阳性表达率分别为45%、9.01%。P-gp和GST-π在各组间比较差异均有统计学意义(P<0.05)MRP1差异无统计学意义(P>0.05)。②NACT后宫颈癌组织中P-pg阳性表达显著上升(P<0.05),有统计学意义。NACT后宫颈癌组织中MRP1、GST-π阳性表达上升但差异无统计学意义(P>0.05)。③新疆维吾尔族妇女新辅助化疗前宫颈鳞癌组织中P-gp、MRP1及GST-π表达阴性和阳性患者NACT有效率无显著性差异(P>0.05)。结论:P-pg、MRP1、GST-π无法作为化疗敏感性指标预测维吾尔族宫颈鳞癌新辅助化疗疗效。
Objective: To investigate the expression of P-gp, MRPI and GST-π before and after neoadjuvant chemotherapy for Uygur cervical cancer in Xinjiang and its relationship with the curative effect of chemotherapy. Methods: The expression levels of P-gp, MRPI and GST-π in 20 cases of cervical squamous cell carcinoma of Uygur women before and after neoadjuvant chemotherapy and normal cervical tissue were detected by S-P method. Results: ①The positive expression rates of P-gp in normal cervical and newly diagnosed cervical cancer tissues in Xinjiang Uigur were 10% and 40.9% respectively. The positive rates of MRP1 were 15% and 31.8% respectively. The positive expression rate of GST-π Respectively, 45%, 9.01%. The difference of P-gp and GST-π in each group was statistically significant (P <0.05). There was no significant difference in MRP1 (P> 0.05). (2) The positive expression of P-pg in cervical cancer tissues after NACT increased significantly (P <0.05), which was statistically significant. The positive expression of MRP1 and GST-π in cervical cancer tissues after NACT increased but the difference was not statistically significant (P> 0.05). ③ There was no significant difference in the NACT efficiency of P-gp, MRP1 and GST-π between the Uygur women with cervical cancer before neoadjuvant chemotherapy and the positive patients (all P> 0.05). Conclusion: P-pg, MRP1 and GST-π can not predict the efficacy of neoadjuvant chemotherapy in Uigur cervical squamous cell carcinoma as a sensitive index of chemotherapy.