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通过观察小鼠负重力竭游泳时间探讨精氨酸-酮戊二酸盐(精酮合剂,AAKG)对小鼠的抗疲劳作用,分别测定小鼠游泳前后血清尿素含量、肝糖原含量、全血乳酸含量等指标以探讨AAKG抗疲劳机制。结果表明,经AAKG处理过的小鼠负重游泳时间(4.71±1.36min)比对照组小鼠(3.01±0.46min)明显延长(P<0.05),AAKG组小鼠血清尿素氮含量(177.94±17.7mg/L)明显低于对照组(202.38±8.95mg/L)(P<0.05),AAKG组小鼠乳酸曲线下面积(85.88±9.74mmol/L)也显著低于对照组(112.82±17.10mmol/L)(P<0.05),而AAKG组小鼠肝糖原含量(11.95±0.35mg/g)显著性高于对照组小鼠(8.42±0.97mg/g)(P<0.05)。本实验结果表明AAKG具有较好的抗疲劳作用,推测与其能够提高小鼠代谢能力和增强应激能力有关。
To observe the anti-fatigue effect of arginine-ketoglutarate (spermine ketones, AAKG) in mice by observing the exhaustive swimming time of mice, and to measure the serum urea content, hepatic glycogen content before and after swimming in mice Blood lactate content and other indicators to explore AAKG anti-fatigue mechanism. The results showed that AAKG-treated mice significantly prolonged the weight-bearing swimming time (4.71 ± 1.36min) compared with the control mice (3.01 ± 0.46min) (P <0.05), and the serum urea nitrogen levels of AAKG mice (177.94 ± 17.7 mg / L) was significantly lower than that of the control group (202.38 ± 8.95mg / L) (P <0.05). The area under the lactate curve of AAKG group was also significantly lower than that of the control group (112.82 ± 17.10mmol / L) /L)(P<0.05). The liver glycogen content of AAKG group (11.95 ± 0.35mg / g) was significantly higher than that of the control group (8.42 ± 0.97mg / g) (P <0.05). The experimental results show that AAKG has a good anti-fatigue effect, suggesting that it can improve the metabolism of mice and enhance the ability of stress.