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目的 :探讨西立伐他汀及普伐他汀对高胆固醇血症患者疗效及安全性。方法 :15 0例高胆固醇血症患者随机分为两组 :西立伐他汀组 75例和普伐他汀组 75例 ,治疗 8周后观察血脂变化和安全性 ,并加以比较。结果 :两种药物均可显著降低总胆固醇 (TC) ,血甘油三酯 (TG) ,低密度脂蛋白 胆固醇 (LDL C) ,并可升高高密度胆蛋白 胆固醇 (HDL C) ,而两药的不良反应无显著差异。结论 :西立伐他汀具有显著的降脂作用 ,在调脂的同时并可抑制血小板活性 ,改善胰岛素抵抗。
Objective: To investigate the efficacy and safety of cerivastatin and pravastatin in patients with hypercholesterolemia. Methods: One hundred and seventy patients with hypercholesterolemia were randomly divided into two groups: 75 patients in the cerivastatin group and 75 patients in the pravastatin group. After 8 weeks of treatment, their blood lipid changes and safety were observed and compared. Results: Both drugs can significantly reduce the total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL C), and can increase high density cholesterol (HDL C), and two drugs No significant difference in adverse reactions. Conclusion: Cerivastatin has significant lipid-lowering effect, which can inhibit platelet activity and improve insulin resistance at the same time of lipid regulation.