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目的：探讨ｂｃｌ－２和ｐ５３蛋白的异常表达与肺癌临床病理因素之间的关系。方法：应用免疫组化方法检测了术后随访５年以上的１２９例肺癌标本中ｂｃｌ－２、ｐ５３蛋白的表达。结果：ｂｃｌ－２及ｐ５３蛋白在肺癌中的阳性表达率分别为２８．７％和５２．７％，两种蛋白表达间呈显著正相关关系。在不同组织学类型中，两种蛋白阳性表达率间无显著差异。淋巴结癌转移阳性组中ｂｃｌ－２蛋白阳性表达率显著高于淋巴结转移阴性组（Ｐ＜０．０５）；而ｐ５３蛋白表达与淋巴结有无癌转移无关。ｂｃｌ－２、ｐ５３蛋白阳性表达者预后显著差于阴性表达者（Ｐ＜０．０１）。ｂｃｌ－２和ｐ５３两种蛋白均阳性表达者的预后及淋巴结癌转移能力与单种蛋白表达阳性及两种蛋白均阴性表达者的差异有显著性（Ｐ＜０．０１）。结论：ｂｃｌ－２和ｐ５３蛋白的异常表达与肺癌的生物学行为密切相关，均可作为评估肺癌预后的有效指标
Objective: To investigate the relationship between the abnormal expression of bcl-2 and p53 protein and the clinicopathological factors of lung cancer. Methods: Immunohistochemistry was used to detect the expression of bcl-2 and p53 protein in 129 lung cancer specimens after 5 years of follow-up. Results: The positive expression rates of bcl-2 and p53 in lung cancer were 28.7% and 52.7%, respectively. There was a significant positive correlation between the two protein expressions. In different histological types, there was no significant difference in the positive expression rates of the two proteins. The positive expression rate of bcl-2 protein in lymph node metastasis-positive group was significantly higher than that in lymph node metastasis-negative group (P<0.05), but the expression of p53 protein was not related to lymph node metastasis or metastasis. The positive expression of bcl-2 and p53 protein was significantly lower than that of negative expression (P<0.01). The positive expression of both bcl-2 and p53 proteins and the metastasis of lymph node metastasis were significantly different from those of positive expression of single protein and negative expression of both proteins (P<0.01). Conclusion: The abnormal expression of bcl-2 and p53 protein is closely related to the biological behavior of lung cancer, and can be used as an effective index to evaluate the prognosis of lung cancer.