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【目的】探讨病毒性肝炎纤维化的病理改变与血清学指标之间的关系。【方法】在彩色B超定位下穿刺取活体肝组织 2 99例 ,作苏木素 伊红 (HE)、网织纤维 (RT)染色 ,显微镜下观察分级、分期。血清标本用放射免疫测定检测透明质酸(HA)、Ⅲ型人前胶原 (HPCⅢ )、IV 型胶原 (IV C)。【结果】慢性肝炎轻度 97例 ,血清学纤维化指标升高不明显。慢性肝炎中度 12 6例 ,血清学纤维化指标均有不同程度升高 ,慢性肝炎重度 2 9例、肝硬化 47例 ,血清学纤维化指标均显著升高。 2 99例慢性病毒性肝炎病理的炎症活动度和纤维化分期与血清学纤维化程度有密切关系。【结论】慢性病毒性肝炎纤维化的病理改变和血清学的变化随临床病情的变化而改变。肝组织活检结合血清学指标的检测在临床上具有较高的诊断价值。
【Objective】 To investigate the relationship between pathological changes of viral hepatitis and serum markers. 【Method】 Two hundred and ninety-two liver tissues were obtained by color B-ultrasound and stained with hematoxylin and eosin (HE) and reticular fibers (RT). The specimens were graded and staged under microscope. Serum samples were detected by radioimmunoassay of hyaluronic acid (HA), type Ⅲ human procollagen (HPC Ⅲ), type IV collagen (IV C). 【Results】 Ninety-seven patients with mild hepatitis had no obvious elevation of serum fibrosis. Moderate chronic hepatitis 12 6 cases, serum fibrosis indicators have increased to varying degrees, 29 cases of severe chronic hepatitis, cirrhosis in 47 cases, serum fibrosis indicators were significantly increased. 2 99 cases of chronic viral hepatitis pathological inflammatory activity and fibrosis staging and serum fibrosis are closely related. 【Conclusion】 The pathological changes and serological changes of chronic viral hepatitis fibrosis change with the clinical condition. Detection of liver biopsy combined with serological indicators in clinical diagnosis with high value.