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应用药动学研究显示志愿者的血浆和唾液咖啡因清除相为一级动力学；半减期分别为３６７．３和２９１．０ｍｉｎ；唾液和血浆的药动学参数有良好的相关性；含体重因素的清除率的变异系数比半减期小；用一次采样测定咖啡因清除率以８ｈ时点为宜。
Pharmacokinetic studies have shown that first phase kinetics of plasma and saliva caffeine clearance in volunteers are 367.3 and 291.0 min respectively; there is a good correlation between pharmacokinetic parameters of saliva and plasma; The coefficient of variation of the clearance rate of body weight factor is smaller than that of the half reduction period. It is advisable to measure the caffeine clearance rate at one time with 8h.