论文部分内容阅读
凝血因子VII是启动外源性凝血途径的重要因子,其在人类生理及病理凝血过程中的作用日益受到重视。尿毒症时凝血因子VII异常可能是此类患者血栓栓塞并发症及心血管源性死亡高发生率的潜在原因,研究此异常及其可能机制对预防和减少血栓栓塞并发症的发生率及死亡率有重要意义。本文综述了尿毒症时凝血因子VII的异常,可能机制及临床意义。
Factor VII is an important factor in initiating the extrinsic coagulation pathway, and its role in the coagulation of human physiology and pathology is gaining more and more attention. Abnormalities in coagulation factor VII during uremia may be the underlying cause for the high incidence of thromboembolic complications and cardiovascular death in these patients, and to investigate the role of this abnormality and its possible mechanisms in preventing and reducing the incidence and mortality of thromboembolic complications There’s important meaning. This article reviews the abnormalities, possible mechanisms and clinical implications of coagulation factor VII during uremia.